Use of a paramagnetic substance, colloidal manganese sulfide, as an NMR contrast material in rats.

摘要: Paramagnetic pharmaceuticals ( magnetopharmaceuticals ) that are suitably distributed into specific organ systems or diseased sites might be clinically useful for tissue contrast enhancement in nuclear magnetic resonance images. To determine whether an insoluble magnetopharmaceutical such service, we investigated the effect of a colloidal preparation manganese sulfide MnSC upon liver and lung spin-lattice relaxation times (T1) rats following intravenous administration. NMR sample measurements were made at 24 MHz, ahd showed after treatment, T1 values--and to lesser extent values--were depressed below control values. Liver content (as determined by flame atomic absorption spectrophotometry) increased proportion dose , reciprocal values also .