Comparison of the biodistribution of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n in mice.
作者： P. Wedeking , M. Tweedle
DOI: 10.1016/0883-2897(88)90009-8
关键词: Biodistribution 、 Gadolinium DTPA 、 Pentetic acid 、 In vivo 、 Gadolinium 、 DOTA 、 Radiochemistry 、 Chemistry 、 Tissue distribution
摘要: The biodistributions of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n were determined in mice at five residence times. Gd(DTPA)2- Gd(DOTA)- had similar distributions with greater than 89% renally excreted 1 h. At 7 days longer after administration, 153Gd bone levels higher could be attributed to free 153Gd3+, suggesting that dechelates vivo. did not appear dechelate. readily clear remained high liver, lungs, spleen for 28 days.
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