What gastric cancer proteomic studies show about gastric carcinogenesis

摘要: Gastric cancer is a complex, heterogeneous, and multistep disease. Over the past decades, several studies have aimed to determine molecular factors that lead gastric development progression. After completing human genome sequencing, proteomic technologies presented rapid progress. Differently from relative static state of genome, cell proteome dynamic changes in pathologic conditions. Proteomic approaches been used profiles identify differentially expressed proteins between groups samples, such as neoplastic nonneoplastic samples or different subtypes stages. Therefore, are useful tool toward improving knowledge pathogenesis understanding tumor heterogeneity. This review summarize protein families frequently identified by using high-throughput screening methods which thus may key role carcinogenesis. The increased carcinogenesis will clearly help new anticancer treatments. Although still their infancy, reviewed be for diagnosis, prognosis, patient management.