Effects of Modulation of Ion Channel Currents by Salidroside in H9C2 Myocardial Cells in Hypoxia and Reoxygenation
作者： Xue-bin Cao , Zhi-hao Jiang , Lei Dong , Yu Zheng , Yang Li
DOI: 10.1155/2019/8212868
关键词:
摘要: Salidroside, a phenyl-propanoid glycoside isolated from the medicinal plant Rhodiola rosea, has potent cardioprotective effects, especially against myocardial hypoxia and reoxygenation injury. However, molecular mechanism underlying its action is still unclear. The aim of this study was to determine effect salidroside on sodium channel current (INa) transient outward potassium (Ito) in H9C2 cardiomyocytes. cells were subcultured under anoxic conditions mimic subsequently treated with salidroside. Whole cell patch clamp performed hypoxia/reoxygenation electrophysiological properties. In differentiated cells, reduced INa Ito amplitude, while significantly restored both altered activation/inactivation kinetics dose-dependent manner. Our findings demonstrate that protects hypoxia-reoxygenation by restoring function channels.
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