Inhibition of Osteoclast Differentiation by Carotenoid Derivatives through Inhibition of the NF-ƙB Pathway.

摘要: The bone protective effects of carotenoids have been demonstrated in several studies, and the inhibition RANKL-induced osteoclast differentiation by lycopene has also demonstrated. We previously reported that carotenoid oxidation products are active mediators activation transcription factor Nrf2 NF-ƙB system carotenoids. Here, we demonstrate more potent than intact inhibiting differentiation. analyzed structure-activity relationship a series dialdehyde derivatives (diapocarotene-dials) osteoclastogenesis. found degree depends on electron density carbon atom determines reactivity conjugated double bond reactions such as Michael addition to thiol groups proteins. Moreover, attenuated signal through IƙB phosphorylation translocation nucleus. In addition, show synergistic combinations an derivative with polyphenols curcumin carnosic acid combination index (CI) values < 1. Our findings suggest inhibit differentiation, partially pathway. can synergistically acid.