Three-dimensional bioprinted hepatorganoids in liver failure.

摘要: We read with interest the recent study by Yang et al , who reported construction of three-dimensional bioprinted hepatorganoids (3DP-HOs) using HepaRG cells and bioinks.1 congratulate authors for this pioneering that demonstrates fabrication in vivo application functional 3DP-HOs mice models liver failure. The would pave way use (3D) primary hepatocytes and/or hepatic progenitor as possible regenerative therapies diseases. However, there are some caveats study, which need to be highlighted. First, showed after 7 days differentiation vitro, expressed marker genes exhibited albumin secretion (figure 2). it is noted most …