Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery.
作者： Wujin Sun , Tianyue Jiang , Yue Lu , Margaret Reiff , Ran Mo
DOI: 10.1021/JA5088024
关键词:
摘要: A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the NCl for enhanced loading capacity of the anticancer drug doxorubicin (DOX). Meanwhile, negatively charged …
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