Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist.
作者： William R. Kelce , Christy R. Stone , Susan C. Laws , L. Earl Gray , Jon A. Kemppainen
DOI: 10.1038/375581A0
关键词:
摘要: The increase in the number of reports abnormalities male sex development wildlife and humans coincided with introduction 'oestrogenic' chemicals such as DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) into environment. Although these phenotypic alterations are thought to be mediated by oestrogen receptor, they also consistent inhibition androgen receptor-mediated events. Here we report that major persistent metabolite, p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), has little ability bind but inhibits binding androgen-induced transcriptional activity, action developing, pubertal adult rats. results suggest induced related environmental may at level receptor.
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