JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism
作者： Karen L. Wu , Hui Miao , Shenaz Khan
DOI: 10.1152/AJPRENAL.00096.2007
关键词:
摘要: von Hippel-Lindau (VHL) disease is a cancer syndrome, which includes renal cell carcinoma (RCC), and caused by VHL mutations. Most, but not all phenotypes are due to failure of mutant to...
sci-hub.se 参考文章(78)
Jo-Anne Vergilio, Adam Bagg, Myeloproliferative Disorders and Myelodysplastic Syndromes Springer, New York, NY. pp. 383- 396 ,(2007) , 10.1007/978-0-387-33227-7_35
Amit Verma, Suman Kambhampati, Simrit Parmar, Leonidas C Platanias, None, Jak family of kinases in cancer. Cancer and Metastasis Reviews. ,vol. 22, pp. 423- 434 ,(2003) , 10.1023/A:1023805715476
Subbian Ananth, Bertrand Knebelmann, Wolfram Grüning, Mohanraj Dhanabal, Gerd Walz, Isaac E Stillman, Vikas P Sukhatme, None, Transforming Growth Factor β1 Is a Target for the von Hippel-Lindau Tumor Suppressor and a Critical Growth Factor for Clear Cell Renal Carcinoma Cancer Research. ,vol. 59, pp. 2210- 2216 ,(1999)
Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. ,vol. 399, pp. 271- 275 ,(1999) , 10.1038/20459
Kim M. Lonergan, Othon Iliopoulos, Michael Ohh, Takumi Kamura, Ronald C. Conaway, Joan Weliky Conaway, William G. Kaelin, Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2 Molecular and Cellular Biology. ,vol. 18, pp. 732- 741 ,(1998) , 10.1128/MCB.18.2.732
Lilly Y. W. Bourguignon, Patrick A. Singleton, Falko Diedrich, Robert Stern, Eli Gilad, CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion Journal of Biological Chemistry. ,vol. 279, pp. 26991- 27007 ,(2004) , 10.1074/JBC.M311838200
Heiwa Okuda, Kojiro Saitoh, Syu-ichi Hirai, Kazuhiro Iwai, Yasuyuki Takaki, Masaya Baba, Nagahiro Minato, Shigeo Ohno, Taro Shuin, The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C Journal of Biological Chemistry. ,vol. 276, pp. 43611- 43617 ,(2001) , 10.1074/JBC.M107880200
John C. Sitko, Claudia I. Guevara, Nicholas A. Cacalano, Tyrosine-phosphorylated SOCS3 Interacts with the Nck and Crk-L Adapter Proteins and Regulates Nck Activation Journal of Biological Chemistry. ,vol. 279, pp. 37662- 37669 ,(2004) , 10.1074/JBC.M404007200
Jinbo Liu, Jeffrey A. Kern, Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation. American Journal of Respiratory Cell and Molecular Biology. ,vol. 27, pp. 306- 313 ,(2002) , 10.1165/RCMB.4850
Heiwa Okuda, Syu-ichi Hirai, Yasuyuki Takaki, Masayuki Kamada, Masaya Baba, Naoki Sakai, Takeshi Kishida, Shigeki Kaneko, Masahiro Yao, Shigeo Ohno, Taro Shuin, Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes Biochemical and Biophysical Research Communications. ,vol. 263, pp. 491- 497 ,(1999) , 10.1006/BBRC.1999.1347