Phase II Study of Trimetrexate, Fluorouracil, and Leucovorin for Advanced Colorectal Cancer
作者： C D Blanke , B Kasimis , P Schein , R Capizzi , M Kurman
DOI: 10.1200/JCO.1997.15.3.915
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摘要: PURPOSEA phase II study to evaluate the response rate and toxicities of a trimetrexate, fluorouracil (5FU), leucovorin regimen in patients with advanced incurable colorectal cancer.PATIENTS AND METHODSThirty-six unresectable or metastatic cancer who had not been treated for disease received following chemotherapy weekly six courses every 8 weeks: trimetrexate 110 mg/m2 intravenously (I.V.) on day 1, 200 I.V. 2 (24 hours later), 5FU 500 immediately leucovorin, oral 15 mg 6 seven doses starting after 5FU. Patients were until progression unacceptable toxicity.RESULTSThirty assessable response, all 36 toxicity. Two (7%) achieved complete (CR) 13 (43%) partial (PR), an overall (OR) 50% (95% confidence interval [CI], 32% 68%). Analysis by intent treat demonst...
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