A novel approach to reversal of neuromuscular blockade.

摘要: Postoperative residual curarization is still a problem of the modern anesthesia. Neostigmine not safest drug that allows safe decurarization, especially when neuromuscular transmission monitoring used. Sugammadex A-cyclodextrin designed to encapsulate rocuronium bromide, providing rapid reversal blockade. It has cardiovascular, respiratory and cholinergic effects. been used in renally impaired patients with no blockade recurrence. reverses either shallow or deep block. Volatile agents such as sevoflurane seems influence sugammadex ability reverse There difference pharmacokinetic children adults. would be able have role future reversing non depolarizing steroidal