HEPATOPROTECTIVE EFFICACY OF PROPOLIS EXTRACT: A BIOCHEMICAL AND HISTOPATHOLOGICAL APPROACH

摘要: Hepatoprotective efficacy of propolis extract (honeybee hive product, 200 mg/kg, p.o.) was studied against carbon-tetrachloride-(CCl 4, 0.15 ml/kg, i.p.) induced biochemical and histopathological changes. Silymarin, a known hepatoprotective drug used as positive control. Subchronic exposure to CCl 4 for 3 weeks (5 days week) caused sharp elevation in the activity liver enzymes i.e. , serum transaminases, alkaline phosphatase lactate dehydrogenase. administration significantly decreased blood glucose level increased proteins. Tissue biochemistry revealed significant reduction total protein glycogen contents, phosphates adenosine triphosphatase along with increase acid both kidney. -induced oxidative stress measured by estimating reduced glutathione amount TBARS formed an index lipid peroxidation. Hepatorenal showed marked depletion whereas peroxidation enhanced significantly. Posttreatment after toxicant reversed five alterations tissue variables including function test markers stress, which similar silymarin-treated Histopathological studies kidney improved cellular architecture therapy confirmed its efficacy. In conclusion, is natural product properties.