Using hydrogen sulfide to design and develop drugs.
作者： Vincenzo Calderone , Alma Martelli , Lara Testai , Valentina Citi , Maria C. Breschi
DOI: 10.1517/17460441.2016.1122590
关键词:
摘要: ABSTRACTIntroduction: Hydrogen sulfide (H2S) is an endogenous gasotransmitter, involved in the regulation of several biological functions. Conversely, impaired biosynthesis H2S associated with important diseases. This paves way for exciting pharmacological perspectives drugs acting on ‘H2S system’.Areas covered: At beginning this manuscript, authors present roles and mechanisms action hydrogen sulfide. The then discuss developments modulation system via heterogeneous molecules, which behave as sources exogenous H2S, are promising a number diseases.Expert opinion: rate generation, physicochemical characteristics bioavailability greatly affect overall profile each H2S-releasing compound. Therefore, development broad collections original moieties endowed rates/mechanisms release variety physicochemical, ph...
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