Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1
作者： Oliver Kaut , Ina Schmitt , Ullrich Wüllner
DOI: 10.1007/S10048-011-0308-3
关键词:
摘要: Multiple lines of evidence suggest a link between environmental toxins and Parkinson's disease (PD). Although numerous studies reported associations genetic variants in de-toxifying enzymes, i.e. cytochrome genes, with PD. Epigenetic modifications genes subsequent altered expression may confer yet unappreciated level susceptibility. We present genome-wide methylation analysis PD quantitative DNA levels 27.500 CpG sites representing 14.495 genes. found decreased the P450 2E1 gene increased CYP2E1 messenger RNA patients' brains, suggesting that epigenetic this contribute to
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