Gastric epithelial dysplasia: The Western perspective

摘要: Abstract The need for early diagnosis of gastric cancer is emphasized by the fact that remains second most common cause related deaths worldwide. aggressive surveillance and definite therapy low high-grade dysplasia, which can be achieved endoscopic means, cornerstone clinical management. Although precursor status dysplasia not contested, its classification controversial fraught with marked inter-observer variations. Most cases have an “intestinal” phenotype referred to as adenomatous dysplasia. Hyperplastic (type II dysplasia) another less variant. progression carcinoma paralleled a stepwise accumulation multiple, but yet uncertain, genetic abnormalities. There are no immunohistochemical or molecular assays stratify certainty risk cancer. Given rate transformation low-grade annual re-biopsy advocated. A indefinite should also prompt surveillance. more ominous, since it progress in cases. However, novel imaging modalities modified management strategies mucosal lesions amenable resection, while surgical resection reserved invasive adenocarcinoma submucosal invasion.