Humanised antibodies to Toll-like receptor 2 and uses thereof
作者： Jerome Dellacasagrande
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摘要: A fully humanised antibody having binding specificity to Toll-like Receptor 2 comprises a light chain and heavy entirely comprised of amino acid sequence human origin. The variable region the an which is substantially homologous with SEQ ID NO:1, while domain NO:4. Also provided are nucleic acids encoding such antibodies, as well use antibodies in medicine, particular for treatment inflammatory autoimmune diseases mediated by activation signalling.
lens.org 参考文章(44)
James S. Huston, Meredith Mudgett-Hunter, Mei-Sheng Tai, John McCartney, Frederick Warren, Edgar Haber, Hermann Oppermann, Protein engineering of single-chain Fv analogs and fusion proteins. Methods in Enzymology. ,vol. 203, pp. 46- 88 ,(1991) , 10.1016/0076-6879(91)03005-2
Guangxun Meng, Hermann Wagner, Carsten Juergen Kirschning, TLR2 antagonistic antibody and use thereof ,(2004)
Alfonso R. Gennaro, Joseph P. Remington, Remington's pharmaceutical sciences Published in <b>1975</b> in Easton Pa) by Mack. ,(1985)
James R. Damewood, Peptide Mimetic Design with the Aid of Computational Chemistry Reviews in Computational Chemistry, Volume 9. pp. 1- 80 ,(2007) , 10.1002/9780470125861.CH1
W V Williams, T Kieber-Emmons, J VonFeldt, M I Greene, D B Weiner, Design of bioactive peptides based on antibody hypervariable region structures. Development of conformationally constrained and dimeric peptides with enhanced affinity. Journal of Biological Chemistry. ,vol. 266, pp. 5182- 5190 ,(1991) , 10.1016/S0021-9258(19)67772-0
G D Chazenbalk, S M McLachlan, S Portolano, J S Hutchison, B Rapoport, Lack of promiscuity in autoantigen-specific H and L chain combinations as revealed by human H and L chain "roulette". Journal of Immunology. ,vol. 150, pp. 880- 887 ,(1993)
David Lane, Ed Harlow, Antibodies: A Laboratory Manual ,(1988)
Joost A. Kolkman, Willem P. C. Stemmer, LDL receptor class A and EGF domain monomers and multimers ,(2004)
Steve Carroll, Arnold H. Horwitz, Marc D. Better, Microbially-produced antibody fragments and their conjugates ,(1992)
Hervé Bachelez, Louis Dubertret, Laurence Michel, Béatrice Flageul, Francette Jean-Louis, Philippe Musette, Isabelle Beaudoin, Edouard Begon, Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin European Journal of Dermatology. ,vol. 17, pp. 497- 506 ,(2007) , 10.1684/EJD.2007.0264