Beta-catenin hits chromatin: regulation of Wnt target gene activation.
作者： Christian Mosimann , George Hausmann , Konrad Basler
DOI: 10.1038/NRM2654
关键词:
摘要: The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution metazoan development, tissue homeostasis and human malignancies. target gene transcription is regulated by nuclear beta-catenin, genetic assays have revealed various collaborating protein cofactors. Their daunting number diverse nature, however, make it difficult arrange an orderly picture of the transduction events. Yet, these findings emphasize that beta-catenin-mediated affects chromatin. How does beta-catenin cope with chromatin regulation turn on genes?
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