TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.
作者： Jiong Li , Cun-Yu Wang
DOI: 10.1038/NCB1684
关键词:
摘要: Aberrant Wnt signalling promotes oncogenesis by increasing the nuclear accumulation of beta-catenin to activate downstream target genes. However, mechanism recruitment target-gene promoter, a critical step for removing co-repressor complex, is largely unknown. Here, we report that transducin beta-like protein 1 (TBL1) and its highly related family member TBLR1 were required Wnt-beta-catenin-mediated transcription. induced interaction between TBL1-TBLR1, as well their binding Importantly, TBL1-TBLR1 promoters was mutually dependent on each other. Furthermore, depletion significantly inhibited Wnt-beta-catenin-induced gene expression oncogenic growth in vitro vivo. Our results unravel two new components function, have important implications developing strategies inhibiting tumorigenesis.
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