Reactive conformations and non-Markovian cyclization kinetics of a Rouse polymer

摘要: We investigate theoretically the physics of diffusion-limited intramolecular polymer reactions. The present work completes and goes beyond a previous study [T. Guerin, O. Benichou, R. Voituriez, Nat. Chem. 4, 568 (2012)10.1038/nchem.1378] that showed distribution conformations at very instant reaction plays key role in cyclization kinetics, takes explicitly into account non-Markovian nature reactant motion. Here, we detail this theory, compare it with existing Markovian theories numerical stochastic simulations. A large focus is made on description non-equilibrium reactive conformations, both analytical tools. show are elongated characterized by spectrum slowly decreasing tail, implying monomers neighbor significantly shifted reaction. complete deri...