Convergent synthesis of aminomethylene peptidomimetics
作者： Naila Assem , Andrei K Yudin
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摘要: This protocol describes a convergent synthesis of reduced amide bond peptidomimetics using thioacid-terminated peptides and aziridine-containing peptide conjugates. approach could be used to produce proteins with modified backbones. The conjugates are made readily available aziridine aldehydes. is demonstrated through the preparation long short fragments an aminomethylene group incorporated within them. transformation amenable bonds at cysteine alanine. procedure each component highlights ease peptidomimetics, takes about 3 d complete.
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