DISCOVERY AND DEVELOPMENT OF ISOZYME‐SELECTIVE INHIBITORS INVOLVED IN LIPID METABOLISM

Linda K Buckett, Alan M Birch, Andrew V Turnbull, DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Current Opinion in Drug Discovery & Development. ,vol. 13, pp. 489- 496 ,(2010)

Daisuke Matsuda, Hiroshi Tomoda, DGAT inhibitors for obesity. Current opinion in investigational drugs. ,vol. 8, pp. 836- 841 ,(2007)

Robert M. Bell, Rosalind A. Coleman, 3 Enzymes of Triacylglycerol Formation in Mammals The Enzymes. ,vol. 16, pp. 87- 111 ,(1983) , 10.1016/S1874-6047(08)60301-7

C.C. Chang, H.Y. Huh, K.M. Cadigan, T.Y. Chang, Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. Journal of Biological Chemistry. ,vol. 268, pp. 20747- 20755 ,(1993) , 10.1016/S0021-9258(19)36846-2

Kimberly K. Buhman, Michel Accad, Sabine Novak, Rebekah S. Choi, Jinny S. Wong, Robert L. Hamilton, Stephen Turley, Robert V. Farese, Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nature Medicine. ,vol. 6, pp. 1341- 1347 ,(2000) , 10.1038/82153

Stefan Ückert, Matthias Oelke, Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction British Journal of Clinical Pharmacology. ,vol. 72, pp. 197- 204 ,(2011) , 10.1111/J.1365-2125.2010.03828.X

, Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial The Lancet. ,vol. 376, pp. 1658- 1669 ,(2010) , 10.1016/S0140-6736(10)60310-8

Drago R. Sliskovic, Joseph A. Picard, Brian R. Krause, ACAT inhibitors: the search for a novel and effective treatment of hypercholesterolemia and atherosclerosis. Progress in Medicinal Chemistry. ,vol. 39, pp. 121- 171 ,(2002) , 10.1016/S0079-6468(08)70070-5

Emile R Mohler, Christie M Ballantyne, Michael H Davidson, Markolf Hanefeld, Luis M Ruilope, Joel L Johnson, Andrew Zalewski, Darapladib Investigators, The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-blind, placebo-controlled study. Journal of the American College of Cardiology. ,vol. 51, pp. 1632- 1641 ,(2008) , 10.1016/J.JACC.2007.11.079

J P Merlie, D Fagan, J Mudd, P Needleman, Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). Journal of Biological Chemistry. ,vol. 263, pp. 3550- 3553 ,(1988) , 10.1016/S0021-9258(18)68959-8