Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor is antagonized by oxidized low-density lipoprotein

摘要: Atherosclerosis is associated with a diminished dilatory response of blood vessels to endothelium-derived relaxing factor (EDRF). To clarify whether this impaired may be due reduced biosynthesis EDRF or responsiveness the smooth muscle guanylate cyclase EDRF, we investigated effects oxidized low-density lipoprotein (LDLox), atherogenic properties, on activation purified soluble by as well activity partially EDRF-forming enzyme.