Diminished capacity to release metabolites of nitric oxide synthase in macrophages loaded with oxidized low-density lipoproteins.
作者： Philippe G. Jorens , Maryvonne Rosseneu , Anne-Marie Devreese , Hidde Bult , Bart Marescau
DOI: 10.1016/0014-2999(92)90082-F
关键词: Lipoprotein 、 Nitrite 、 Lipopolysaccharide 、 Low-density lipoprotein 、 Nitric oxide synthase 、 ATP synthase 、 Biochemistry 、 Chemistry 、 Nitric oxide 、 Citrulline
摘要: Abstract Activation of J774-macrophages with lipopolysaccharide (LPS) or LPS and recombinant interferon-γ (IFN-γ) induced nitric oxide (NO) synthase activity, as measured by the production nitrite citrulline. NO activity was suppressed loading cells oxidatively modified low-density lipoprotein (ox-LDL) but not acetylated LDL (ac-LDL), although intracellular lipid accumulation comparable. This suggests that extent activation lipid-loaded macrophages may be influenced type lipid.
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