Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.
作者： F C Tanner , G Noll , C M Boulanger , T F Lüscher
关键词: Cardiology 、 Nitric oxide 、 Medicine 、 Coronary arteries 、 Bradykinin 、 Platelet 、 Internal medicine 、 Scavenger receptor 、 Low-density lipoprotein 、 Endothelium 、 Endothelium-derived relaxing factor 、 Endocrinology
摘要: BACKGROUNDWe studied the effects of low density lipoprotein (LDL) on endothelium function.METHODS AND RESULTSPorcine epicardial and intramyocardial coronary arteries suspended in organ chambers for isometric tension recording were exposed to LDL 2 hours then washed. In arteries, oxidized (30-300 micrograms/ml) but not native or lysolecithin inhibited endothelium-dependent relaxations serotonin, thrombin, aggregating platelets (5,000-75,000/microliter). Endothelium-dependent bradykinin A23187 endothelium-independent SIN-1 unaffected by LDL. had no appreciable effect serotonin. The response serotonin was completely prevented dextran sulfate (10 micrograms/ml). inhibitory persisted presence pertussis toxin. Similar lipoproteins, L-N...
sci-hub.se 参考文章(29)
William B. Kannel, Contribution of the framingham study to preventive cardiology Journal of the American College of Cardiology. ,vol. 15, pp. 206- 211 ,(1990) , 10.1016/0735-1097(90)90203-2
M. T. Quinn, S. Parthasarathy, L. G. Fong, D. Steinberg, Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 2995- 2998 ,(1987) , 10.1073/PNAS.84.9.2995
Martha K. Cathcart, Diane W. Morel, Guy M. Chisolm, Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. Journal of Leukocyte Biology. ,vol. 38, pp. 341- 350 ,(1985) , 10.1002/JLB.38.2.341
T. Henriksen, E. M. Mahoney, D. Steinberg, Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 6499- 6503 ,(1981) , 10.1073/PNAS.78.10.6499
T Henriksen, E M Mahoney, D Steinberg, Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 3, pp. 149- 159 ,(1983) , 10.1161/01.ATV.3.2.149
S Ylä-Herttuala, W Palinski, M E Rosenfeld, S Parthasarathy, T E Carew, S Butler, J L Witztum, D Steinberg, Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. Journal of Clinical Investigation. ,vol. 84, pp. 1086- 1095 ,(1989) , 10.1172/JCI114271
G. Michael Vincent, Jeffrey L. Anderson, Hiram W. Marshall, Coronary Spasm Producing Coronary Thrombosis and Myocardial Infarction The New England Journal of Medicine. ,vol. 309, pp. 220- 223 ,(1983) , 10.1056/NEJM198307283090406
Marek W Radomski, Richard MJ Palmer, Salvador Moncada, None, The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochemical and Biophysical Research Communications. ,vol. 148, pp. 1482- 1489 ,(1987) , 10.1016/S0006-291X(87)80299-1
Hiroshi Azuma, Masayuki Ishikawa, Satomi Sekizaki, Endothelium‐dependent inhibition of platelet aggregation British Journal of Pharmacology. ,vol. 88, pp. 411- 415 ,(1986) , 10.1111/J.1476-5381.1986.TB10218.X
H. E. Andrews, K. R. Bruckdorfer, R. C. Dunn, M. Jacobs, Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature. ,vol. 327, pp. 237- 239 ,(1987) , 10.1038/327237A0