Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta.
作者： Michael Jacobs , Frances Plane , K. Richard Bruckdorfer
DOI: 10.1111/J.1476-5381.1990.TB12045.X
关键词: Lagomorpha 、 Aorta 、 Mechanism of action 、 Endocrinology 、 Agonist 、 Phenylephrine 、 Chemistry 、 Nitric oxide 、 Endothelium-derived relaxing factor 、 Acetylcholine 、 Internal medicine
摘要: 1. The effect of native low-density lipoproteins (LDL) and oxidized LDL (OXLDL) on the relaxations to endothelium-derived relaxing factor (EDRF) in isolated, intact aortic rings rabbit were investigated. 2. Native induced a concentration-dependent reversible inhibition elicited by acetylcholine (ACh) or A23187, pre-contracted noradrenaline (NA), adrenaline (Ad) 5-hydroxytryptamine (5-HT), but not phenylephrine (PE), which was influenced indomethacin. 3. surmountable with NA Ad only partially those 5-HT. 4. OXLDL an ACh A23187 independent contractile agonist. extent its reversibility varied from individual donors, unaffected 5. inhibited evoked exogenous nitric oxide (NO) same extent. Higher concentrations NO overcame inhibition. agonist preparation donors. 6. Only reversibly glyceryl trinitrate (GTN) 7. This study demonstrates that influence response EDRF isolated aorta. We suggest these may contribute attenuation responses found arteries hypercholesterolaemic atherosclerotic animals.
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