Venoconstrictor activity of some precursor fractions of stable plasma protein solution.

摘要: . Stable plasma protein solution (SPPS) is a 5% of human albumin and some globulins. Rapid infusion batches SPPS analogous solutions prepared by similar processes induce paradoxical hypotensive reactions. In the current experiments, number precursor fractions single batch were examined for kininogen content venoconstrictor activity on isolated central vein rabbit ear. Unheated contained both kininogen. Among various examined, Cohn fraction II+III (a III—0) greatest activity. There was no evidence depletion during stages frac-tionation but generation material. Column chromatog-raphy suggested molecular weight approximately 1,500 major active material in unheated SPPS. It appears possible that 14-amino acid peptide present III-0 may also be SPPS, where it contribute to effects this solution.