Mood Stabilizing Drugs Expand the Neural Stem Cell Pool in the Adult Brain Through Activation of Notch Signaling

摘要: Neural stem cells (NSCs) have attracted considerable attention as a potential source of for therapeutic treatment impaired areas the central nervous system. However, efficient and clinically feasible strategies expansion endogenous NSC pool are currently unavailable. In this study, we demonstrate that mood stabilizing drugs, which used to treat patients with bipolar disorder, enhance self-renewal capability mouse NSCs in vitro enhancement is achieved at therapeutically relevant concentrations cerebrospinal fluid. The pharmacological effects mediated by activation Notch signaling NSC. Treatment stabilizers increased an active form receptor upregulated its target genes neural stem/progenitor cells, whereas coculture γ-secretase inhibitor or presence mutation presenilin1 gene blocked stabilizers. addition, chronic administration expanded adult brain, subsequently cell supply olfactory bulb. We suggest drugs could be facilitate regeneration following insult system. Disclosure conflicts interest found end article.