The value of fluorine-18 fluorodeoxyglucose PET in patients with medullary thyroid cancer.

摘要: The early detection of metastases from medullary thyroid cancer (MTC) is important because the only curative therapy consists in surgical removal all tumour tissue. There no single sensitive diagnostic imaging modality for localization patients with MTC. Therefore, many cases several modalities (e.g. ultrasonography, magnetic resonance imaging, computerized tomography and scintigraphy using pentavalent technetium-99m dimercaptosuccinic acid, thallium-201 chloride, indium-111 pentetreotide, anti-CEA antibodies or metaiodobenzylguanidine) must be performed consecutively elevated calcitonin levels until localized. In this prospective study, we investigated value fluorine-18 fluorodeoxyglucose positron emission ([18F]FDG PET) follow-up [18F]FDG PET examinations neck chest were 20 sonographic abnormalities neck. Positive findings validated by histology, selective venous catheterization. detected 13/17 (nine four tomography). Five showed completely negative scans (of these cases, one was true-negative false-negative). One patient accumulation pulmonary lesions silicosis a lesion that not subjected to histological validation had excluded. Considering localizations, 12/14 manifestations neck, 6/7 mediastinal metastases, 2/2 bone metastases. two levels, able localize tumour. sensitivity MTC 76% (95% confidence interval 53%–94%); encouraging. promises valuable method, especially lymph node resection which can result complete remission.