Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia
作者： M. V. Alfimova , V. E. Golimbet , G. I. Korovaitseva , T. V. Lezheiko , L. I. Abramova
DOI: 10.1007/S11055-015-0119-3
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摘要: Existing data point to a link, within the general population, between polymorphic variants of serotonin transporter gene (5-HTTLPR SLC6A4) and catechol-O-methyltransferase on one hand processing information related emotional facial expressions other. Schizophrenia patients are characterized by defi cit in recognition mimicked expressions, which has adverse effects their social adaptation. With aim seeking molecular mechanisms this cit, we have assessed main epistatic these polymorphisms emotions among schizophrenia (n = 299) healthy control subjects 232). The 5-HTTLPR polymorphism showed signifi cant relationship with patients. Homozygotes for long allele identifi ed cantly better than carriers short (F 8.00, p 0.005). Although group correlated negative symptoms, verbal learning, trait anxiety, signs did not modifying influences association detected here. COMT was found no effect either normal or
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