A second transport ATPase gene in Saccharomyces cerevisiae.
作者： A Schlesser , S Ulaszewski , M Ghislain , A Goffeau
DOI: 10.1016/S0021-9258(19)77659-5
关键词:
摘要: A second transport ATPase gene from Saccharomyces cerevisiae has been identified by hybridization to a PMA1 probe and sequenced. The called PMA2 encodes polypeptide of Mr = 102,157, which, with the exception 144 amino-terminal residues, is highly homologous structural for H+-ATPase. It localized on chromosome XVI at 16.7 centimorgan gal4 not essential haploid growth. Comparison between upstream, noncoding DNA regions indicates that two genes are controlled differently. extensive amino acid sequence homology fungal H+-ATPases described so far PMA2-encoded protein also able function as H+ pump. This supported observation in pma1 mutants reduced plasma membrane activity, disruption confers ability grow under alkaline pH conditions. Slower development diploids observed normal minimal medium after bilateral parents.
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