Modulation of toll-like receptor function has therapeutic potential in autoimmune disease.

摘要: Importance of the field: The role toll-like receptors (TLRs) in immune response to exogenous pathogens is well characterized. These have been suggested be involved initiation and/or perpetuation many inflammatory autoimmune diseases and become attractive candidates for modulation inflammation. Areas covered this review: This review discusses evidence support a potential TLRs diseases, focusing on rheumatoid arthritis, multiple sclerosis systemic lupus erythematosus. approaches targeting TLR activation are outlined. What reader will gain: An appreciation particular contribution specific focuses recent developments activity from ligand binding through resultant signaling. Take home message: As initiators responses, previously targeted increase with some success. However, attenuate responses treatment chronic require further mechanisms involvement pathophysiology better understanding effects modulating physiology over sustained period.