Toll-Like Receptors in Idiopathic Orbital Inflammation

摘要: PURPOSE A prior investigation has demonstrated that innate immune-specific cytokines are enriched in idiopathic orbital inflammation (IOI). To further document the role of immunity IOI, authors sought to determine whether toll-like receptors (TLRs) present biopsy specimens this disorder. METHODS Immunohistochemical staining for TLR2, TLR3, and TLR4 was performed on taken from patients with number TLR-positive cells counted across five 40× light microscopic fields. These results were compared an isotype control adipose tissue without evidence inflammation. RESULTS All IOI positivity all 3 TLRs, sections stained controls did not demonstrate any positivity. Furthermore, significant signal. The mean positive 24.4 cells/high power field (hpf; standard deviation = 11.6 cells/hpf), 7.23 cells/hpf (standard 5.59 11.7 TLR4, respectively. CONCLUSIONS This study provides first documentation TLRs disease. Toll-like may represent aberrant immune response. Interference additional potential therapeutic mechanism management IOI.