Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases.

摘要: Oxysterols, or cholesterol oxidation products, are oxygenated derivatives of which formed endogenously during the biosynthesis bile acids and steroid hormones. In addition, oxysterols may also be absorbed from diet as they found in many commonly consumed foods. Oxysterols have been shown to possess potent diverse biological activities, study effects these products on human body forms a wide field research. The results most research efforts support conclusion that certain oxysterols, predominantly those oxidized low-density lipoprotein, exert pathological such induction apoptotic cell death. Moreover, apoptosis induced by has strongly implicated pathogenesis atherosclerosis well variety other diseases. oxysterol-induced is an emerging area, following review aims provide detailed account chronology events involved. Current evidence involvement death receptor pathway protein kinases examined important regulators mitochondria, B-cell lymphoma-2 proteins caspases. effect gene expression, interactions membrane properties discussed.