Effect of 1-Butyl-3-methylimidazolium Ibuprofenate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) on the Thermodynamic Properties of Glycine and l -Alanine in Aqueous Solutions at Different Temperatures

摘要: Recently, ionic liquids have been combined with active pharmaceutical ingredients (APIs), and a third generation of ILs has emerged (API-ILs). The effect novel liquid containing the ibuprofenate anion as an ingredient (API-IL) on thermodynamic properties two amino acids, glycine l-alanine, studied. densities, speeds sound, viscosities refractive indices l-alanine in water aqueous solutions API-IL, 1-butyl-3-methylimidazolium ([BMIM][Ibu]), determined at temperatures 288.15–318.15 K. measured data used to calculate standard partial molar volume $$ V_{\phi }^{0} $$ , transfer \Delta_{\text{tr}} Hepler’s constant (\partial^{2} /\partial T^{2} )_{p} apparent isentropic compressibility \kappa_{\phi } refraction R D, viscosity B coefficient (B) hydration number parameters n H. All these are discussed terms competitive interactions occurring between acids–[BMIM][Ibu] acids–water.