Partitioning of Ciprofloxacin in aqueous two-phase system of poly(ethylene glycol) and sodium sulphate
作者： Babak Mokhtarani , Ramin Karimzadeh , Mohammad Hassan Amini , Siavash Darvish Manesh
DOI: 10.1016/J.BEJ.2007.07.009
关键词:
摘要: Extraction by an aqueous two-phase system is a powerful technique for separation, concentration, and purification of biomolecules pharmaceutical products. In the present study, partitioning Ciprofloxacin in PEG–Na2SO4–water has been investigated. The influences temperature, salt polymer concentration molecular weight on were studied. experiments designed using orthogonal central composite design (orthogonal CCD) based 2 3 full factorial second-order model was used to determine effects different factors partitioning. results indicate that highly dependent concentration. Temperature PEG have moderate but no significant effect antibiotic © 2007 Elsevier B.V. All rights reserved.
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