Altered Gene Expression in Tumor Metastasis: The nm23 Gene

摘要: Tumor metastasis is a complex process involving tumor cell invasion, locomotion, intravasation and extravasation of the circulatory system, angiogenisis, colony formation, avoidance host immunological responses. Two premises have guided our investigation into genetic influences on invasion metastasis. First, if metastatic regulated, at least in part, by activation deactivation specific genes, then multiplicity functions dictates that many genes are involved. Second, biochemical nature molecules regulating executing each metastatis incompletely understood. Because tedious purification process, it likely regulatory effector compounds encoding them presently unknown. Based these premises, we initiated differential hybridization experiments to identify associated with process. This technique identifies either activated or deactivated between cells low high potential. It can therefore metastasis-related advance conventional DNA cloning. paper describes identification characterization one such gene, nm23.