Intravenous mesenchymal stem cell therapy for traumatic brain injury.
作者： Matthew T. Harting , Fernando Jimenez , Hasan Xue , Uwe M. Fischer , James Baumgartner
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摘要: Object Cell therapy has shown preclinical promise in the treatment of many diseases, and its application is being translated to clinical arena. Intravenous mesenchymal stem cell (MSC) been improve functional recovery after traumatic brain injury (TBI). Herein, authors report on their attempts reproduce such observations, including detailed characterizations MSC population, non–bromodeoxyuridine-based labeling, macroscopic microscopic tracking, quantification cells traversing pulmonary microvasculature, well-validated measurement motor cognitive function recovery. Methods Rat MSCs were isolated, expanded vitro, immunophenotyped, labeled. Four million intravenously infused into Sprague-Dawley rats 24 hours receiving a moderate, unilateral controlled cortical impact TBI. Infrared tracking was used identify distribution. Immunohistochemical analysis lung tissues 48 2 we...
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Reed E. Pyeritz, Malcolm K. Brenner, Edwin M. Horwitz, Darwin J. Prockop, Lorraine A. Fitzpatrick, Winston W. K. Koo, Patricia L. Gordon, Michael Neel, Michael Sussman, Paul Orchard, Jeffrey C. Marx, Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta Nature Medicine. ,vol. 5, pp. 309- 313 ,(1999) , 10.1038/6529
Eric Lagasse, Heather Connors, Muhsen Al-Dhalimy, Michael Reitsma, Monika Dohse, Linda Osborne, Xin Wang, Milton Finegold, Irving L. Weissman, Markus Grompe, Purified hematopoietic stem cells can differentiate into hepatocytes in vivo Nature Medicine. ,vol. 6, pp. 1229- 1234 ,(2000) , 10.1038/81326
Omer N. Koç, Stanton L. Gerson, Brenda W. Cooper, Stephanie M. Dyhouse, Stephen E. Haynesworth, Arnold I. Caplan, Hillard M. Lazarus, Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy Journal of Clinical Oncology. ,vol. 18, pp. 307- 316 ,(2000) , 10.1200/JCO.2000.18.2.307
Ulf Krause, Christoph Harter, Anja Seckinger, David Wolf, Adrian Reinhard, Florian Bea, Thomas Dengler, Stefan Hardt, Anthony Ho, Hugo A. Katus, Helmut Kuecherer, Alexander Hansen, Intravenous delivery of autologous mesenchymal stem cells limits infarct size and improves left ventricular function in the infarcted porcine heart. Stem Cells and Development. ,vol. 16, pp. 31- 38 ,(2007) , 10.1089/SCD.2006.0089
Neil D Theise, Diane S Krause, Saul Sharkis, Comment on "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells" Science. ,vol. 299, pp. 1317a- 1317 ,(2003) , 10.1126/SCIENCE.1078412
Denis English, Stephen K. Klasko, Paul R. Sanberg, Elusive mechanisms of "stem cell"-mediated repair of cerebral damage. Experimental Neurology. ,vol. 199, pp. 10- 15 ,(2006) , 10.1016/J.EXPNEUROL.2006.03.005
Ryo Ukai, Osamu Honmou, Kuniaki Harada, Kiyohiro Houkin, Hirofumi Hamada, Jeffery D. Kocsis, Mesenchymal stem cells derived from peripheral blood protects against ischemia. Journal of Neurotrauma. ,vol. 24, pp. 508- 520 ,(2007) , 10.1089/NEU.2006.0161
Raymond F Castro, Kathyjo A Jackson, Margaret A Goodell, Claudia S Robertson, Hao Liu, H David Shine, None, Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science. ,vol. 297, pp. 1299- 1299 ,(2002) , 10.1126/SCIENCE.297.5585.1299
April Breyer, Nima Estharabadi, Masayuki Oki, Fernando Ulloa, Molly Nelson-Holte, Laura Lien, Yuehua Jiang, Multipotent adult progenitor cell isolation and culture procedures. Experimental Hematology. ,vol. 34, pp. 1596- 1601 ,(2006) , 10.1016/J.EXPHEM.2006.07.013
J. F. Guzowski, J. L. McGaugh, Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 2693- 2698 ,(1997) , 10.1073/PNAS.94.6.2693