Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

摘要: Metabolic activities in normal cells rely primarily on mitochondrial oxidative phosphorylation (OXPHOS) to generate ATP for energy. Unlike cells, glycolysis is enhanced and OXPHOS capacity reduced various cancer cells. It has long been believed that the glycolytic phenotype due a permanent impairment of OXPHOS, as proposed by Otto Warburg. This view challenged recent investigations which find function most cancers intact. Aerobic many combined result factors such oncogenes, tumor suppressors, hypoxic microenvironment, mtDNA mutations, genetic background others. Understanding features complexity energy metabolism will help develop new approaches early diagnosis effectively target therapy cancer.