Pilot Results of the Early Detection by Ultrasound of Carotid Artery Intima–Media Thickness Evaluation (EDUCATE) Study

摘要: Background Limitations of current models for risk stratification are known. Noninvasive imaging is being advocated as an adjunct to improve prediction; however, studies documenting outcomes rare. Therefore, we aimed evaluate the negative and positive predictive values carotid atherosclerosis future cardiovascular events. Methods The Early Detection by Ultrasound Carotid Artery intima media Thickness Evaluation (EDUCATE) study prospectively enrolled 253 consecutive young middle-aged adults undergoing elective coronary angiography. Bilateral ultrasound lipid profiles were performed. was defined thickness ≥1.0 mm in main body, or focal plaque within bulb, proximal branch. Future events included major (death, myocardial infarction, stroke) minor (revascularization new onset heart failure). Results Of patients 236 completed all tests; mean age 51 ± 8 years; 58% women. Sensitivity, specificity, predicting severe artery disease 72%, 49% 79%, with odds ratio (OR) 2.2 (95% confidence interval [CI] 1.2–4.0). suffering events, 90% had atherosclerosis. Only 1 95 without experienced a event. Kaplan-Meier analysis revealed differences event-free survival favor subjects (P = .051) any event .015). Cox hazard (HR) 2.7 CI 1.2–6.2; P .020) relationship remained significant after adjusting traditional factors (HR 2.5, 95% 1.1–5.9; .034). Conclusions associated Negative excellent prognosis.