Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers.
作者： Zhi Liu , Peng Hou , Meiju Ji , Haixia Guan , Kimberly Studeman
DOI: 10.1210/JC.2008-0273
关键词:
摘要: Context: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-kinase (PI3K)/Akt MAPK pathways have not been fully defined anaplastic follicular thyroid cancers [anaplastic cancer (ATC), (FTC)]. Objective: The objective of the study was to explore a wide-range genetic basis for involvement these ATC. Design: We examined mutations copy number gains large panel genes corresponding phosphorylation ERK (p-ERK) Akt. Results: found frequent RTK genes, including EGFR, PDGFRα -β, VEGFR1 2, KIT, MET PIK3Ca, PIK3Cb, PDK1 PI3K/Akt pathway. Mutations Ras, PTEN, BRAF RET/PTC rearrangements were common, whereas PDK1, Akt1, Akt2, uncommon Overall, 46 48 ATC (95.8%) harbored at least one alteration, coexistence two or more seen 37 (77.1%)....
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