Aspirin and Reye Syndrome

摘要: Reye syndrome is an extremely rare but severe and often fatal disease. Death occurs in about 30–40% of cases from brainstem dysfunction. The disease typically preceded by a viral infection with intermediate disease-free interval 3–5 days. biochemical explanation for Reye-like symptoms generalized disturbance mitochondrial metabolism, eventually resulting metabolic failure the liver other tissues. etiology ‘classical’ unknown. Hypothetically, may result unusual response to preceding infection, which determined host genetic factors can be modified variety exogenous agents. Thus, several infections diseases might present clinically symptoms. Exogenous agents involve number toxins, drugs (including aspirin [acetylsalicylic acid]), chemicals. ‘rise fall’ incidence still poorly understood unexplained. With few exceptions, there were probably no new reported during last 10 years that could not explained inherited disorder metabolism or misdiagnosis. This reflect scientific progress better understanding cellular molecular dysfunctions as disease-determining factors. Alternatively, immune virulence virus have changed alteration its code. suggestion defined cause-effect relationship between intake children supported sufficient facts. Clearly, drug treatment without side effects. balanced view whether certain justified terms benefit/risk ratio always necessary. Aspirin exception.