Reticular Drusen associated with Geographic Atrophy in Age-related Macular Degeneration

摘要: PURPOSE To characterize reticular drusen (RDR) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) a prospective, multicenter, natural history study. METHODS Confocal scanning laser ophthalmoscopy (cSLO) three-field fundus autofluorescence (FAF; exc., 488; em., 500-700 nm), near-infrared reflectance (IR; 820 and blue (BR; 488 nm) images as well red-free (RF) color (CF) camera photographs were recorded 458 GA patients. The digital evaluated by two independent readers subsequent senior reader arbitration for prevalence topographic distribution of RDR using modified Early Treatment Diabetic Retinopathy Study grid. RESULTS detected at least one cSLO modality 286 (62%) either eye (bilateral 207 [45%]) visible 66 371 (18%) 48 [13%]). Prevalence imaging was associated increasing age (P = 0.007) female sex 0.007), but not total lesion area 0.38). Cohen kappa statistics showed good interobserver agreement FAF (0.81) IR (0.82) modes, moderate found BR (0.48), RF CF (0.40). On present most frequently superior the fovea (99%). CONCLUSIONS represent common phenotypic hallmark eyes. are readily identified technology. These observations may explain high determined herein, contrast previous reports based on photographs. Incorporation these novel modalities future studies facilitate efforts aimed defining role predictive value progression AMD. (ClinicalTrials.gov number, NCT00599846.)