Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non-small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis.

摘要: The surgical treatment of patients with advanced lung cancer remains controversial. current study aimed to identify the factors affecting prognosis stage IV non-small cell (NSCLC) and clarify surgery guidelines. A total 27,725 diagnosed NSCLC were selected from Surveillance, Epidemiology, End Results program between 2010 2013. sex, age, ethnicity, marital status, Tumor-Node-Metastasis stage, radiation therapy received status each patient recorded. Patients followed up November 2015. Survival rates estimated by Kaplan-Meier method. Single- multi-factor analyses performed using log-rank test multivariate Cox regression analysis respectively. In isolated organ metastasis cohort, liver alone had worst prognosis, a median overall survival (OS) 4 months (liver vs. other metastases; P<0.001). only best OS 8 (lung Furthermore, one 6 (single multiple-organ isolated-organ cohort metastases revealed that who ≤60 years, female, married, Asian, N0 bone metastasis, accepted wedge resection or lobectomy primary tumor, procedure distant lymph node(s), beam an improved compared patients. Age, tumor type, N number type metastatic lesions, lesions are which influence NSCLC. may still benefit these