Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome

摘要: Huntington's disease is characterised by hyperkinetic movements, mainly chorea, cognitive dysfunction, and psychiatric abnormalities. Non-dopa responsive parkinsonism occurs in the later stages of choreic or as predominant feature juvenile patients (Westphal variant). Late onset presenting levodopa rare. A series four with late cardiovascular dysautonomia, initially misdiagnosed multiple system atrophy (MSA) three patients, reported. Levodopa treatment did not unmask significant chorea. These cases suggest presence a distinct phenotypic variant to be added differential diagnosis other akinetic rigid syndromes.