Deep brain stimulation for Huntington's disease: long-term results of a prospective open-label study.
作者： Victoria Gonzalez , Laura Cif , Brigitte Biolsi , Sara Garcia-Ptacek , Anne Seychelles
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摘要: Object To date, experience of globus pallidus internus (GPi) deep brain stimulation (DBS) in the treatment Huntington's disease (HD) has been limited to a small number case reports. The aim this study was analyze long-term motor outcome cohort HD patients treated with GPi DBS. Methods Seven pharmacologically resistant chorea and functional impairment were included prospective open-label from 2008 2011. main measure section Unified Disease Rating Scale. primary end point reduction chorea. Results Patients underwent MRI-guided bilateral implantation. median duration follow-up 3 years. A significant observed all patients, sustained therapeutic effect; mean improvement on subscore 58.34% at 12-month visit (p = 0.018) 59.8% 3-year 0.040). Bradykinesia dystonia showed nonsignificant trend toward progre...
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