Deep brain stimulation in Huntington's disease: assessment of potential targets.
作者： Mayur Sharma , Milind Deogaonkar
DOI: 10.1016/J.JOCN.2014.11.008
关键词: Chorea 、 Neuroscience 、 Huntington's disease 、 Disease 、 Thalamotomy 、 Pallidal stimulation 、 Neuromodulation (medicine) 、 Deep brain stimulation 、 Medicine 、 Search terms
摘要: Abstract Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder that has very few effective therapeutic interventions. Since the a defined neural circuitry abnormality, neuromodulation could be option. Case reports, original research, and animal model studies were selected from databases of Medline PubMed. All related published up to July 2014 included in this review. The following search terms used: “Deep brain stimulation,” “DBS,” “thalamotomy,” “pallidal “Huntington’s Disease,” “HD,” “chorea,” or “hyperkinetic movement disorders.” This review examines potential nodes HD modulated using deep stimulation (DBS) therapy. With rapid evolution imaging ability reach difficult targets with refined DBS technology, some phenotypes potentially treated near future. Further clinical are warranted validate efficacy determine most optimal target for HD.
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