The burden of scientific progress: Growing inequalities in the delivery of cancer care

作者: Max Mano

DOI: 10.1080/02841860500341181

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摘要: Novel targeted therapies are now a reality in oncology. The monoclonal antibodies trastuzumab, rituximab, cetuximab and bevacizumab have proven benefit both advanced early stage cancers. Furthermore impressive new technologies such as gene profiling, circulating tumour cells proteomics becoming major tools for prognostic assessment prediction of response to certain treatments. Whilst this is certainly good news patients it comes at price, many these very expensive may result unprecedented inequalities the delivery cancer care. largest impact be on developing countries, but starting felt some developed nations. Strategies tackle resource implications need addressed alongside development technologies.

参考文章(10)
Margaret A. Shipp, Ken N. Ross, Pablo Tamayo, Andrew P. Weng, Jeffery L. Kutok, Ricardo C.T. Aguiar, Michelle Gaasenbeek, Michael Angelo, Michael Reich, Geraldine S. Pinkus, Tane S. Ray, Margaret A. Koval, Kim W. Last, Andrew Norton, T. Andrew Lister, Jill Mesirov, Donna S. Neuberg, Eric S. Lander, Jon C. Aster, Todd R. Golub, Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning Nature Medicine. ,vol. 8, pp. 68- 74 ,(2002) , 10.1038/NM0102-68
Scott L. Pomeroy, Pablo Tamayo, Michelle Gaasenbeek, Lisa M. Sturla, Michael Angelo, Margaret E. McLaughlin, John Y. H. Kim, Liliana C. Goumnerova, Peter M. Black, Ching Lau, Jeffrey C. Allen, David Zagzag, James M. Olson, Tom Curran, Cynthia Wetmore, Jaclyn A. Biegel, Tomaso Poggio, Shayan Mukherjee, Ryan Rifkin, Andrea Califano, Gustavo Stolovitzky, David N. Louis, Jill P. Mesirov, Eric S. Lander, Todd R. Golub, Prediction of central nervous system embryonal tumour outcome based on gene expression Nature. ,vol. 415, pp. 436- 442 ,(2002) , 10.1038/415436A
Jenny C Chang, Eric C Wooten, Anna Tsimelzon, Susan G Hilsenbeck, M Carolina Gutierrez, Richard Elledge, Syed Mohsin, C Kent Osborne, Gary C Chamness, D Craig Allred, Peter O'Connell, Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer The Lancet. ,vol. 362, pp. 362- 369 ,(2003) , 10.1016/S0140-6736(03)14023-8
Charles L. Vogel, Elizabeth Tan-Chiu, Trastuzumab Plus Chemotherapy: Convincing Survival Benefit or Not? Journal of Clinical Oncology. ,vol. 23, pp. 4247- 4250 ,(2005) , 10.1200/JCO.2005.12.903
M. Ayers, W.F. Symmans, J. Stec, A.I. Damokosh, E. Clark, K. Hess, M. Lecocke, J. Metivier, D. Booser, N. Ibrahim, V. Valero, M. Royce, B. Arun, G. Whitman, J. Ross, N. Sneige, G.N. Hortobagyi, L. Pusztai, Gene Expression Profiles Predict Complete Pathologic Response to Neoadjuvant Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy in Breast Cancer Journal of Clinical Oncology. ,vol. 22, pp. 2284- 2293 ,(2004) , 10.1200/JCO.2004.05.166
Michel Marty, Francesco Cognetti, Dominique Maraninchi, Ray Snyder, Louis Mauriac, Michèle Tubiana-Hulin, Stephen Chan, David Grimes, Antonio Antón, Ana Lluch, John Kennedy, Kenneth O’Byrne, PierFranco Conte, Michael Green, Carol Ward, Karen Mayne, Jean-Marc Extra, Randomized Phase II Trial of the Efficacy and Safety of Trastuzumab Combined With Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Administered As First-Line Treatment: The M77001 Study Group Journal of Clinical Oncology. ,vol. 23, pp. 4265- 4274 ,(2005) , 10.1200/JCO.2005.04.173
Marc J. van de Vijver, Yudong D. He, Laura J. van 't Veer, Hongyue Dai, Augustinus A.M. Hart, Dorien W. Voskuil, George J. Schreiber, Johannes L. Peterse, Chris Roberts, Matthew J. Marton, Mark Parrish, Douwe Atsma, Anke Witteveen, Annuska Glas, Leonie Delahaye, Tony van der Velde, Harry Bartelink, Sjoerd Rodenhuis, Emiel T. Rutgers, Stephen H. Friend, René Bernards, A Gene-Expression Signature as a Predictor of Survival in Breast Cancer The New England Journal of Medicine. ,vol. 347, pp. 1999- 2009 ,(2002) , 10.1056/NEJMOA021967
Yixin Wang, Jan GM Klijn, Yi Zhang, Anieta M Sieuwerts, Maxime P Look, Fei Yang, Dmitri Talantov, Mieke Timmermans, Marion E Meijer-van Gelder, Jack Yu, Tim Jatkoe, Els MJJ Berns, David Atkins, John A Foekens, Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. The Lancet. ,vol. 365, pp. 671- 679 ,(2005) , 10.1016/S0140-6736(05)17947-1
Dennis J. Slamon, Brian Leyland-Jones, Steven Shak, Hank Fuchs, Virginia Paton, Alex Bajamonde, Thomas Fleming, Wolfgang Eiermann, Janet Wolter, Mark Pegram, Jose Baselga, Larry Norton, Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2 The New England Journal of Medicine. ,vol. 344, pp. 783- 792 ,(2001) , 10.1056/NEJM200103153441101