Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
作者： Bijay S. Jaiswal , Vasantharajan Janakiraman , Noelyn M. Kljavin , Subhra Chaudhuri , Howard M. Stern
DOI: 10.1016/J.CCR.2009.10.016
关键词:
摘要: Members of the mammalian phosphoinositide-3-OH kinase (PI3K) family proteins are critical regulators various cellular process including cell survival, growth, proliferation, and motility. Oncogenic activating mutations in p110alpha catalytic subunit heterodimeric p110/p85 PI3K enzyme frequent human cancers. Here we show presence p85alpha colon cancer, a majority which occurs inter-Src homology-2 (iSH2) domain. These uncouple retain p85alpha's p110-stabilizing activity, while abrogating its p110-inhibitory activity. The mutants promote AKT activation, anchorage-independent oncogenesis p110-dependent manner.
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