DNA-binding, DNA cleavage and cytotoxicity studies of two anthraquinone derivatives
作者： M.B. Gholivand , S. Kashanian , H. Peyman
DOI: 10.1016/J.SAA.2011.11.045
关键词:
摘要: Abstract The interaction of native calf thymus DNA (CT-DNA) with two anthraquinones including quinizarin (1,4-dihydroxy anthraquinone) and danthron (1,8-dihydroxy in a mixture 0.04 M Brittone–Robinson buffer 50% ethanol were studied at physiological pH by spectrofluorometric cyclic voltammetry techniques. former technique was used to calculate the binding constants anthraquinones–DNA complexes different temperatures. Thermodynamic study indicated that reactions both anthraquinone–DNA systems are predominantly entropically driven. Furthermore, mechanisms on reaction effect ionic strength fluorescence property system have also been investigated. results experiments modes evaluated be groove binding. Moreover, cytotoxic activity compounds against human chronic myelogenous leukemia K562 cell line cleavage these slightly pUC18 plasmid showed minor antitumor (human myeloid leukemia) line.
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Eleni K. Efthimiadou, Hellinida Thomadaki, Yiannis Sanakis, Catherine P. Raptopoulou, Nikos Katsaros, Andreas Scorilas, Alexandra Karaliota, George Psomas, Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,2'-bipyridine. Journal of Inorganic Biochemistry. ,vol. 101, pp. 64- 73 ,(2007) , 10.1016/J.JINORGBIO.2006.07.019
Yoshio Ueno, Kiyoko Umemori, Eei-Chi Niimi, Sei-Ichi Tanuma, Satoshi Nagata, Masao Sugamata, Tomomi Ihara, Masaru Sekijima, Ken-Ichi Kawai, Ikuko Ueno, Fumio Tashiro, Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Natural Toxins. ,vol. 3, pp. 129- 137 ,(1995) , 10.1002/NT.2620030303
Danith Ly, Laurie Sanii, Gary B. Schuster, Mechanism of Charge Transport in DNA: Internally-Linked Anthraquinone Conjugates Support Phonon-Assisted Polaron Hopping Journal of the American Chemical Society. ,vol. 121, pp. 9400- 9410 ,(1999) , 10.1021/JA991753S
Jie Liu, Tixiang Zhang, Tongbu Lu, Lianghu Qu, Hui Zhou, Qianling Zhang, Liangnian Ji, DNA-binding and cleavage studies of macrocyclic copper(II) complexes Journal of Inorganic Biochemistry. ,vol. 91, pp. 269- 276 ,(2002) , 10.1016/S0162-0134(02)00441-5
Kuei-Ying Lin, Mark Matteucci, Hybridization properties of deoxyoligonucleotides containing anthraquinone pseudonucleosides. Nucleic Acids Research. ,vol. 19, pp. 3111- 3114 ,(1991) , 10.1093/NAR/19.11.3111
Mitsunobu Nakamura, Masayuki Ueda, Sayuri Watanabe, Satoshi Kumamoto, Kazushige Yamana, Syntheses of anthraquinone capped hairpin DNAs and electrochemical redox responses from their self-assembled monolayers on gold electrode Tetrahedron Letters. ,vol. 48, pp. 6159- 6162 ,(2007) , 10.1016/J.TETLET.2007.06.153
A. M. Pyle, J. P. Rehmann, R. Meshoyrer, C. V. Kumar, N. J. Turro, Jacqueline K. Barton, Mixed-ligand complexes of ruthenium(II): factors governing binding to DNA Journal of the American Chemical Society. ,vol. 111, pp. 3051- 3058 ,(1989) , 10.1021/JA00190A046
D. Jancura, S. Sánchez-cortés, E. Kocisova, A. Tinti, P. Miskovsky, A. Bertoluzza, Surface‐enhanced resonance raman spectroscopy of hypericin and emodin on silver colloids: SERRS and NIR FTSERS study Biospectroscopy. ,vol. 1, pp. 265- 273 ,(1995) , 10.1002/BSPY.350010405
L. S. Lerman, The structure of the DNA-acridine complex. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 49, pp. 94- 102 ,(1963) , 10.1073/PNAS.49.1.94
Akira Ono, Akihito Dan, Akira Matsuda, Nucleosides and nucleotides. 121. Synthesis of oligonucleotides carrying linker groups at the 1'-position of sugar residues. Bioconjugate Chemistry. ,vol. 4, pp. 499- 508 ,(1993) , 10.1021/BC00024A012