Molecular Pathways of Drug Resistance
作者： Linda E. Bröker , José A. Rodriguez , Giuseppe Giaccone
DOI: 10.1007/978-1-59259-664-5_14
关键词:
摘要: Despite significant advances in the treatment of solid tumors and hematologic malignancies, clinical drug resistance to anticancer therapy is still a frequent problem that often leads failure cancer patients. Resistance chemotherapy can be divided into intrinsic (or de novo) acquired resistance. The former refers are insensitive cytotoxic drugs at diagnosis, such as pancreatic cancer, renal malignant melanoma. Acquired common breast small-cell lung (SCLC), ovarian initially highly responsive therapy, but become resistant during course disease. These develop not only previously used drugs, also other compounds with different structures mechanisms action which they have never been exposed.
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